CORDIS Project
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This project explores the regulatory mechanisms of the 20S proteasome, a key player in protein degradation. It aims to uncover how this pathway operates independently of ubiquitin, focusing on the molecular and cellular factors that control its activity.
For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation.
However, it is now becoming clear that proteins can also be targeted for degradation by a ubiquitin-independent mechanism mediated by the core 20S proteasome itself.
Although initially believed to be limited to rare exceptions, degradation by the 20S proteasome is now understood to have a wide range of substrates, many of which are key regulatory proteins.
Despite its im…
WEIZMANN INSTITUTE OF SCIENCE
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