CORDIS Project
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This research focuses on understanding genetic robustness in biological systems, particularly how gene redundancy and interactions contribute to resilience against mutations. By studying model organisms, it aims to uncover mechanisms that could inform our understanding of genetic diseases in humans.
Most genes are not required for viability.
This robustness to mutation is a fundamental property of complex biological systems but the mechanism(s) underlying it and how it evolves is unclear.
It has been proposed that robustness can result from genetic redundancy through gene duplication and the distributed nature of biological networks.
The robustness of both yeast and C. elegans has been dissected using genetic interaction screens, where combinations of mutations are screened for a synthetic…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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