CORDIS Project
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This project focuses on using native mass spectrometry to study protein complexes and their functions in biological systems. By employing advanced techniques, it aims to enhance our understanding of protein interactions and their implications in health and disease.
Native mass spectrometry (MS) is a powerful structural biology tool to study protein complexes, their dynamics, assembly and function.
In its so-called top-down approach, it aims to link specific proteoforms to higher assemblies such as non-covalent complexes, in which they function naturally and/or in a disease.
The proposed project will leverage the power and versatility offered by state-of-the-art Fourier transform ion cyclotron resonance (FTICR) mass spectrometry coupled to ultraviolet and i…
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