CORDIS Project
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This project aims to develop a high-resolution imaging method to observe proton fluxes in living cells using a special two-dimensional material. By mapping the activity of proton channels, particularly the Hv1 channel, the research seeks to enhance understanding of their role in diseases like cancer and stroke.
Proton channels in cells and the corresponding transmembrane proton fluxes are critical for many cell activities.
Recent studies reveal that expression levels of proton channel Hv1 and its activity are highly associated with the development of many diseases, including cancer spreading, disrupted bone metabolism, and stroke, which makes proton channel an interesting therapeutic target.
Yet, the full understanding of the mechanism of proton flux-related disease development is still under developme…
TECHNISCHE UNIVERSITEIT EINDHOVEN
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