CORDIS Project
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This project focuses on developing a new RNA-based therapeutic tool, 2shRNA, designed to combat drug resistance in breast cancer. By targeting two pathways simultaneously, it aims to enhance treatment efficacy while minimizing toxicity, potentially improving patient outcomes with fewer doses.
This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system.Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment.
Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability.
We have designed and synthesized 2shRNA, a new bifuncti…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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