CORDIS Project
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This project investigates how common genetic variations influence the three-dimensional structure of chromatin and gene activity related to type-two diabetes risk. It utilizes advanced mapping techniques to analyze genetic interactions in human islets, aiming to identify non-coding variants that contribute to disease s…
Despite the worldwide growing incidence of type-two diabetes (T2D), the molecular mechanisms are largely unknown.
Genome Wide Association Studies (GWAS) have identified dozens of loci harbouring common SNPs that affect T2D susceptibility.
The host lab recently showed that many associated SNPs lie in clusters of islet-specific regulatory elements that form tridimensional chromatin structures in the nucleus.
This project aims to evaluate how common genetic variation could impact the tridimensional…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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