CORDIS Project
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The project investigates the mechanisms of homologous recombination, a critical DNA repair process, and its role in meiosis. By developing innovative experimental techniques, it aims to enhance understanding of how cells accurately identify and repair DNA breaks, which is essential for genetic stability and reproductio…
Homologous recombination (HR) is a conserved DNA double-strand breaks (DSB) repair pathway that uniquely uses an intact DNA molecule as a template.
Genome-wide homology search is carried out by a nucleoprotein filament (NPF) assembled on the ssDNA flanking the DSB, and whose product is a “D-loop” joint molecule.
Beyond accurate DSB repair, this capacity of HR to spatially associates homologous molecules is also harnessed for homolog pairing in meiosis.
The goal of “3D-loop” is to tackle two long…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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