CORDIS Project
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This research focuses on visualizing the Xist long non-coding RNA and its associated particles in mouse embryonic stem cells using advanced imaging techniques. The goal is to understand its molecular mechanisms, which play a crucial role in female mammal development and various diseases.
Recent studies have highlighted a pivotal role for long non-coding RNAs (lncRNAs) in normal physiology and disease.
As a key example, Xist lncRNA is crucial during the early development of female mammals and is involved in many diseases, e.g. progeria and cancers.
To date, cellular and developmental studies have advanced our knowledge of the function of Xist, but a detailed understanding of molecular mechanism is lacking.Therefore, the overarching aim of my proposed research is to directly visua…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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