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The 3DMASH project investigates metabolic dysfunction-associated steatohepatitis (MASH), a liver disease linked to obesity. By utilizing patient-derived tissue cultures, it aims to uncover the interactions between various tissues and identify new targets for potential pharmacological treatments for this serious conditi…
Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent liver disease that affects up to 6% of the general population and 15-40% of obese persons. MASH is characterized by intracellular triglyceride accumulation (steatosis), chronic inflammation and hepatocyte injury.
Importantly, MASH is prone to progress into liver fibrosis, cirrhosis and hepatocellular carcinoma and, even if diagnosed early, the disease is associated with reductions in life expectancy of 2-4.5 years.
Despite tr…
KAROLINSKA INSTITUTET
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