CORDIS Project
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This project aims to characterize cell-matrix adhesion complexes during cell migration in three-dimensional environments. By using advanced imaging techniques, it will investigate how these complexes behave differently in 3D compared to traditional 2D systems, providing insights into cell migration mechanisms.
Integrin-mediated cell-matrix adhesion complexes (CMACs) are important modulators of cell adhesion and migration and are key transducers of cell signaling events.
In cell migration, correct coordination of CMAC adhesive strength and signaling is pivotal.
Cell migration has been extensively studied in 2D cell culture systems, and while studies in more physiological 3D environments are still rudimentary, it is already clear that CMACs behave very differently in 3D environments as compared to 2D. T…
KAROLINSKA INSTITUTET
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