CORDIS Project
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The 3DVasCMD project aims to create a humanized 3D vascularized cardiac model to study coronary microvascular disease. By integrating advanced tissue-engineering techniques and induced pluripotent stem cells, the project seeks to uncover the mechanisms of disease and identify potential therapeutic targets for better ca…
Coronary microvascular disease (CMD) is a significant healthcare challenge, contributing to ischemic heart disease, the number one global cause of human mortality. CMD is associated with dysfunction of small coronary vessels, due to ageing, obesity and metabolic disease, that reduces blood flow and oxygenation in the heart.
Despite its widespread impact on health, our understanding is limited to animal studies, which do not recapitulate the pathophysiology in humans, nor can they be used to reve…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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