CORDIS Project
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This project investigates how metabolic processes in monocytes influence inflammation and recovery after myocardial infarction. By studying metabolic changes over time in both mouse models and human cohorts, the research aims to identify pathways that can be targeted to improve heart function and reduce heart failure r…
Cardiovascular diseases (CVD), particularly myocardial infarction (MI), are partly driven by chronic inflammation, in which myeloid cells, such as monocytes and macrophages, play a central role.
This project aims to elucidate the metabolic mechanisms regulating monocyte function and their impact on post-MI recovery.
Emerging evidence suggests that the metabolic state of myeloid progenitor cells and their descendants critically influences their pro- or anti-inflammatory functions.
While glycolysi…
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