CORDIS Project
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The 3Stops2Go project investigates the unique genetic decoding mechanisms in protists, particularly focusing on how certain tRNAs interpret codons differently. This research aims to develop engineered tRNAs and drugs to address genetic diseases caused by premature termination codons, potentially transforming treatment…
An accumulating body of evidence reveals that the Genetic Code, canonically interpreted in codons of three nucleotides, is not universal.
In dogma challenging findings, we have observed in unicellular protists a remarkable malleability of genetic decoding that is mostly governed by tRNAs that interpret codons as having different meanings depending on their location in the genome.
For example, coding sequences of our model protist Blastocrithidia nonstop are rich in stop codons and unique tRNA ar…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Czechia, Ceske Budejovice
Type: Research institute
Activity type: Research Organisations
SME: No
France, GIF-SUR-YVETTE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
France, Paris
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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