CORDIS Project
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This project focuses on the NLRP6 inflammasome's role in regulating the intestinal microbiome and its impact on health and disease. By investigating host-microbiome interactions, the research aims to uncover mechanisms that could lead to personalized therapies for metabolic syndrome.
Nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins have emerged as central regulators of immunity and inflammation.
Several NLRs form cytosolic multi-protein complexes termed inflammasomes in response to pathogen and damage- associated molecular patterns.
We recently identified the NLRP6 inflammasome as a critical innate immune regulator of the intestinal microbiome, a diverse ecosystem whose poorly understood interactions with the host influence a multitude of physiologica…
WEIZMANN INSTITUTE OF SCIENCE
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