CORDIS Project
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This project focuses on creating a large-scale, functional human heart muscle patch using purified human ventricular progenitors. By optimizing their self-assembly and enhancing their growth and maturation through specific factors, the aim is to develop effective therapies for heart regeneration in patients with ischem…
Developing new therapeutic strategies for heart regeneration is a major goal for cardiac biology and medicine.
While cardiomyocytes can be generated from human pluripotent stem (hPSC) cells in vitro, it has proven difficult to use these cells to generate a large scale, mature human heart ventricular muscle graft on the injured heart in vivo.
The central objective of this proposal is to optimize the generation of a large-scale pure, fully functional human ventricular muscle patch in vivo through…
KAROLINSKA INSTITUTET
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