CORDIS Project
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This project investigates the role of CD44, a glycoprotein involved in cell signaling, in cancer development. It focuses on understanding how its intracellular domain contributes to cell transformation and tumorigenesis.
CD44 is a type I transmembrane glycoprotein highly polymorphic expressed in most tissues.
The single gene can give rise to many different transcripts, named CD44 variants. CD44 represents the principal receptor for the main matrix glycosaminoglucan component, the hyaluronic acid (Ponta et al., 2003). CD44 is a multifunctional protein involved in lymphocyte homing and activation, cell migration or apoptosis. CD44 functions are modulated by metalloproteases that cleave the extracellular part of CD…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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