CORDIS Project
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This project investigates the role of Transforming Growth Factor-beta signaling in cancer, focusing on the activation of specific proteins (Smad1 and Smad5) and their implications for tumor progression. The research aims to identify the receptor complexes involved and the genes activated by this signaling pathway, pote…
Ligands of the Transfroming Growth Factor-beta (TGF-beta) superfamily control numerous cellular processes such as proliferation, apoptosis, differentiation, adhesion and mobility.
As a result, it is well established that they play an essential role in cancer. TGF-beta signalling has been implicated in both tumour suppression and progression. TGF-beta signals predominantly through receptor-regulated Smads (R-Smads), Smad2 and Smad3, but several lines of evidence from the Hill’s lab suggest that T…
CANCER RESEARCH UK LBG
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