CORDIS Project
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This project investigates the roles of cyclic nucleotides in the human pathogen Listeria monocytogenes, focusing on the production of cyclic adenosine monophosphate and cyclic guanosine monophosphate. It aims to uncover their signaling pathways and contributions to the bacterium's virulence mechanisms.
Nucleotides are the building blocks of nucleic acids and have emerged as significant determinants in energy transfer and signalling.
Four nucleotides are known to function as signalling molecules in bacteria, namely the cyclic mono-nucleotides cAMP and cGMP, and the cyclic di-nucleotides c-di-AMP and c-di-GMP.
These molecules play specific and distinct roles in many bacterial species, and can co-exist within a single bacterial cell.
Whereas the diversity of cyclic nucleotide signalling is now st…
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