CORDIS Project
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This project explores the dual role of the A20 protein in inflammation and apoptosis within endothelial cells and neutrophils. It aims to identify A20's interactions and functions to uncover potential therapeutic targets for autoimmune vasculitis.
The ubiquitin editing protein A20, a novel 90kDa zinc-finger protein has an universal anti-inflammatory activity by inhibiting NF-kappaB activation.
In endothelial cells, the induction of A20 by inflammatory stimuli renders cells resistant to apoptosis.
However, A20 can have pro-apoptotic activities in other cell types.
We will focus on the respective role of A20 in both endothelial cells and neutrophils, two cardinal cell players in inflammation associated with autoimmune vasculitis in which A2…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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