CORDIS Project
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AAVolution focuses on enhancing liver-directed gene therapy using adeno-associated vectors (AAV). The project aims to overcome challenges such as transient gene expression, immune responses, and pre-existing immunity to improve treatment access for patients with liver diseases.
Liver-directed gene therapy has undergone significant development in the last two decades.
Recombinant adeno-associated vectors (AAV) are the vectors of choice for liver gene transfer and have recently achieved remarkable successes in clinical trials.
However, there are still large groups of patients who have limited access to therapy.
The major hurdles toward expanding the indication of AAV-mediated liver gene therapy are: i) transient AAV-mediated expression in proliferating hepatocytes, i.e.…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, Pozzuoli
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
NEXT GENERATION DIAGNOSTIC SRL
Italy, Pozzuoli
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
Italy, Trento
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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