CORDIS Project
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This project focuses on developing small ring azabicyclic amines, which have unique properties relevant for drug discovery. By creating access to these compounds and exploring their functionalization, the project aims to introduce new bioisosteres and scaffolds that can enhance drug design and development in medicinal…
Small ring azabicyclic amines are predicted to possess unique molecular properties, but lack of synthetic access has to date prevented their thorough evaluation and deployment in high value functional molecules, including drugs.
Much recent attention has focused on small-ring carbocyclic frameworks such as bicyclo[1.1.1]pentanes (BCPs), but analogous azabicyclic compounds are poorly described in the literature, which is surprising given the ubiquity of amines in bioactive organic molecules. A li…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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