CORDIS Project
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This project investigates a newly discovered family of membrane protein complexes that transport vitamins in Gram-positive bacteria. It aims to understand their unique transport mechanisms, protein interactions, and potential as targets for new antibacterial drugs.
Many Gram-positive (pathogenic) bacteria are dependent on the uptake of vitamins from the environment or from the infected host.
We have recently discovered the long-elusive family of membrane protein complexes catalyzing such transport.
The vitamin transporters have an unprecedented modular architecture consisting of a single multipurpose energizing module (the Energy Coupling Factor, ECF) and multiple exchangeable membrane proteins responsible for substrate recognition (S-components).
The S-co…
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