CORDIS Project
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This project explores the role of amyloid beta peptide in regulating synaptic function in the brain, particularly in the context of Alzheimer's disease. It aims to understand how this peptide influences neurotransmission and synaptic strength.
Amyloid beta peptide (Abeta) is a normal product of the amyloid precursor protein (APP) proteolysis in the brain.
While Abeta synaptotoxicity has been extensively studied as central to Alzheimer's disease (AD) pathogenesis, the mechanisms by which physiological Abeta regulates synapse function remain unknown.
Utilizing two-photon excitation laser scanning microscopy combined with fluorescence lifetime imaging, FM-based imaging of synaptic vesicle recycling at the single-synapse level and electro…
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