CORDIS Project
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This project explores the role of immune responses in atherosclerosis, particularly how defective clearance of dead cells contributes to disease progression. It aims to identify critical pathways involved in inflammation and immune tolerance breakdown to improve cardiovascular disease management.
Atherosclerosis is a chronic inflammatory disease of the arterial wall with (auto)immune component, initiated in response to modified (phospho)lipids.
Despite important advances in our understanding of the inflammatory response in atherosclerosis, the critical pathways responsible for the breakdown of immune tolerance to lipoproteins and other self-antigens remain largely unknown.
An important feature of ruptured/thrombosed atherosclerotic lesions is the accumulation of apoptotic, and secondary…
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