CORDIS Project
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This project investigates how the hypothalamic preoptic area regulates body temperature and energy balance. It explores the role of a molecular temperature sensor, transient receptor potential melastatin 2, to understand thermoregulation and its potential therapeutic applications for obesity.
Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations.
The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore.
Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits con…
UNIVERSITATSKLINIKUM HEIDELBERG
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