CORDIS Project
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This project investigates Lamin A/C cardiomyopathy using a novel three-dimensional human heart tissue model derived from patient-specific stem cells. It aims to understand disease mechanisms and explore potential treatments through gene editing and pharmacological approaches.
Lamin A/C cardiomyopathy (LMNA-CM) is a rare genetic disorder caused by mutations in the nuclear lamin gene LMNA.
Affected patients typically exhibit dilated cardiomyopathy and reduced life expectancy, due to sudden cardiac death or accelerated functional decay requiring the heart transplant.
Intriguingly, carriers of the same LMNA mutation show a wide spectrum of genotype-phenotype discrepancy, however a clear mechanistical understanding remains elusive.
Recently, the host laboratory has develo…
UNIVERSITA DEGLI STUDI DI PADOVA
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