CORDIS Project
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This project aims to elucidate the roles of histone acetyltransferases in regulating gene expression and cellular functions by identifying their non-histone protein substrates. It employs advanced proteomic techniques to study the acetylation patterns in human cells.
Histone acetyltransferases (HATs) play a critical role in regulating gene expression of many cellular functions.
Interestingly, the vision of histones being unique substrates for different HATs has recently changed, since HATs can also regulate essential functions such as protein turnover or cell cycle progression, via acetylation of non-histone proteins. HATs and their acetylation activity must have multiple physiological roles, which are still poorly understood.
This is especially the case of…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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