CORDIS Project
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This project investigates the process of transdifferentiation in pancreatic acinar cells, focusing on the molecular mechanisms and signaling pathways involved. By utilizing an in vitro system, the research aims to understand how these cells can convert into precursor-like cells, with potential applications in treating…
Cellular metaplasia may occur by transdifferentiation of one mature cell type into another, sometimes via an intermediate state of dedifferentiation.
This type of cellular plasticity seems to be found in adult pancreatic acinar cells.
The loss of differentiation may turn the acinar cells in facultative stem cells in the adult pancreas.
Both in regeneration of exocrine as well as endocrine tissue and in pancreatic disease states, this type of acinar-derived precursor cells has found to be implica…
VRIJE UNIVERSITEIT BRUSSEL
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