CORDIS Project
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This project focuses on understanding the molecular mechanisms behind the biosynthesis of gladiolin, a compound active against drug-resistant tuberculosis. It aims to utilize advanced NMR techniques to investigate the dynamics of proteins involved in this process for potential drug development.
Antibiotics are a vital part of modern medicine.
However, the available arsenal of antibiotics becomes less effective as microorganisms develop ""resistance"" against them.
The resulting crisis in medicine necessitates development of new drugs.
Natural products inspired compounds are a potential solution to this challenge.
For example, gladiolin biosythesized by a mulitenzyme polyketide synthase (PKS) was shown to be active against Mycobacterium tuberculosis, a multidrug resistant bacterium that…
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