CORDIS Project
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This study explores the role of histone deacetylase 1 in anxiety and depression using mouse models. It aims to uncover molecular mechanisms that could enhance the effectiveness of antidepressant treatments by understanding gene expression changes in response to stress.
The discovery that broad spectrum histone deacetylase inhibitors (HDACi) can improve depression-related symptoms in humans and in corresponding mouse models in conjunction with the observation that stressors affect the epigenome by changing histone acetylation opened new avenues to a better understanding of the pathophysiology of stress-related disorders.
Finding the essential molecular mechanisms of how single histone deacetylases (HDACs) contribute to or ameliorate stress-related pathologies w…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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