CORDIS Project
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This project investigates how bacterial pathogens manipulate the host's actin cytoskeleton to facilitate their movement within cells. By studying the atomic structures of bacterial proteins involved in this process, it aims to uncover mechanisms that could lead to new treatments for infections.
Actin and its associated regulatory proteins are fundamental components of the cytoskeleton, playing a central role in nearly every process in eukaryotes.
Remarkably, the intracellular pathogens Shigella and Listeria have evolved specialized proteins, known as effectors, to hijack this crucial system of the host.
These effectors induce actin polymerization on the bacterial surface, allowing the pathogens to propel themselves within and between host cells through a process called actin-based moti…
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