CORDIS Project
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This project studies the relationship between nuclear shape and cancer behavior. It aims to understand how nuclear morphology affects genome integrity and cell migration, using advanced imaging techniques to analyze the role of actin regulators in these processes.
Nuclear shape is one of the gold standards for detection and characterization of cancers.
Nonetheless the control of nuclear morphology and its relationship to malignant behaviors are still poorly understood.
We propose to study the mechanisms that lead to nuclear dysmorphia and their consequence on nuclear functions such as genome integrity and migration.
The first part of the research will start from a list of actin regulators that, in preliminary experiments, showed role in controlling nuclea…
THE FRANCIS CRICK INSTITUTE LIMITED
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