CORDIS Project
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This research investigates how the nematode C. elegans senses and responds to varying oxygen levels. It aims to identify the molecular mechanisms behind acute oxygen sensing and tolerance to anoxia, with implications for understanding human health.
Oxygen (O2) levels can vary enormously in the environment, which induces dramatic behavioral and physiological changes to resident animals.
Adaptations to O2 variations can be either acute or sustained.
How animals detect and respond to the changes of O2 availability remains elusive at the molecular level.
In particular, what is the precise mechanism of acute O2 sensing, what are the primary sensor for acute hypoxia, and why do neurons of various species exhibit completely different sensitivity…
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