CORDIS Project
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This project explores the role of novel histone modifications in gene regulation, particularly in relation to metabolic disorders. It aims to create a genome-wide map of histone acylations in single cells to understand their influence on transcription.
Regulation of transcription is orchestrated by a complex combination of histone posttranslational modifications (PTMs), but how their co-occurrence in the same cell regulate gene expression is still poorly understood.
Recently, novel histone acylations have been identified, namely propionylation (pr) and butyrylation (bu).
They co-exist with acetylation (ac), arise from cellular metabolism, and are key candidates to fine-tune chromatin activity and transcription.
This project will answer fundame…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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