CORDIS Project
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This project aims to develop a novel treatment for glioblastoma multiforme by creating a masked nanobody-drug conjugate that can penetrate the blood-brain barrier and selectively target glioma stem cells. The approach seeks to minimize side effects while effectively treating this aggressive brain tumor.
Glioblastoma multiforme (GBM) is one of the most prevalent brain tumours and is currently incurable.
Patients die from tumour recurrence after resection and chemotherapy.
New treatments need to overcome two great challenges: reaching the tumour margins, where the blood-brain barrier (BBB) is intact, and eradicating glioma stem cells (GSCs), which cause tumour relapse.
Targeting receptors overexpressed on cancer cells with antibody-drug conjugates (ADC) has shown great promise in cancer treatment…
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