CORDIS Project
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This project investigates how the morphogenesis of surface ectoderm and somitic mesoderm influences neural tube closure during embryonic development. By utilizing model organisms like Xenopus laevis and mice, the research aims to understand the mechanical interactions that contribute to neural tube defects, a common bi…
Neural tube closure (NTC) is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system.
Defective NTC leads to neural tube defects (NTDs), which are one of the most common human birth defects.
During NTC Convergent Extension (CE) leads to the narrowing and elongation of the neural plate (NP) and Apical Constriction (AC) drives the bending of the tissue.
While the role of the aforementioned morphogenetic events for NTC has been studied exten…
UNIVERSITY OF CYPRUS
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