CORDIS Project
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This project focuses on identifying DNA modifications caused by genotoxic substances, which may lead to cancer. Using advanced mass spectrometry techniques, it aims to discover biomarkers for colorectal cancer risk through the analysis of DNA adducts in human samples.
Covalent modCovalent modification of DNA by exogenous genotoxic molecules can translate into gene alteration, possibly inducing carcinogenesis.
The analysis of DNA modifications, referred to as DNA-adducts, is fundamental for assessing the mechanism of action of genotoxic molecules.
Nowadays, high resolution mass spectrometry (HRMS) is one of the most promising technique for DNA-adduct identification.
Despite DNA adductomics by HRMS is highly promising, it is a new born field, presenting several…
KOBENHAVNS UNIVERSITET
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