CORDIS Project
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This project investigates how manipulating the Keap1/Nrf2 signaling pathway in fat tissue influences obesity and metabolic syndrome. By creating mouse models with altered Nrf2 functions, the research aims to clarify the mechanisms behind obesity development and the role of fat tissue in energy metabolism and insulin re…
This research addresses the question of how the manipulation of Keap1/Nrf2 signaling in adipose tissue affects the development of obesity and metabolic syndrome.
Nrf2 is a central orchestrator of a battery of antioxidant and cytoprotective genes in response to oxidative or electrophilic stress and there is growing evidence that it cross-talks with other pathways.
Our previous works showed that the whole body deletion of Nrf2 protected, at least partially, mice from high-fat diet (HFD)-induced ob…
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