CORDIS Project
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This project explores the interplay between two protein modifications, ubiquitination and ADP-ribosylation, which are crucial for cellular functions such as immune response and DNA repair. It aims to uncover mechanisms and develop inhibitors for therapeutic applications in diseases like cancer.
Post-translational modification of proteins is essential in regulating proper cellular homeostasis.
The attachment and removal of the small protein Ubiquitin (Ub) is amongst others involved in regulating immune response, cell cycle progression and proteasome mediated protein degradation.
The (de)conjugation of adenosine-di-phosphate ribose (ADPr) on the other hand is essential in regulating DNA damage responses and apoptosis. ADPribosylation and ubiquitination both dictate a highly complex signa…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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