CORDIS Project
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This project aims to explore how exogenous amyloid beta aggregates can trigger the aggregation of endogenous amyloid beta in neuronal cells, which may contribute to neurodegenerative diseases like Alzheimer's. It will investigate the molecular mechanisms involved and the role of various factors in this process.
Amyloid fibrils are likely causative or contributing agents in diseases such as Alzheimer’s disease, type 2 diabetes, Parkinson’s disease, and transmissible spongiform encephalopathies. AD represents a major health problem and heavy economic burden in industrialized countries. AD is characterized in pathology by the presence of several kinds of amyloid plaques in the brain patients.
The main component of these plaques is the amyloid beta peptide (Ab).
Because Ab is suspected to play a crucial ro…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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