CORDIS Project
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This project examines the role of the adventitia, the outer layer of blood vessels, in the progression of atherosclerosis. It aims to identify how inflammation and adipocyte activity influence plaque stability, potentially leading to new treatments for cardiovascular diseases.
Background:
The clinical outcome of cardiovascular diseases such as myocardial infarction and stroke is generally caused by rupture or erosion of an atherosclerotic plaque.
While the contribution of the plaque intima and media to plaque initiation and progression are well acknowledged, that of the arterial perivascular tissue, the adventitia, is not established yet.
Hypothesis:
Adventitial inflammation, which is partially modulated by adipocyte activity, profoundly impacts plaque progression an…
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