CORDIS Project
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This project aims to understand the relationship between protein structural dynamics and the aggregation of the ataxin-3 protein, which is implicated in certain diseases. By combining advanced nuclear magnetic resonance techniques and computational methods, the research will focus on the early misfolding events that le…
The present proposal aims to study the relationships existing between protein structural dynamics and pathological aggregation of the multidomain N-terminal part of the polyglutamine (polyQ) protein ataxin-3.
By means of an integrated approach combining advanced NMR and computational techniques, the applicant plans to investigate low frequencies native-like states responsible of aberrant protein-protein interactions leading to first amyloid aggregates.
These species in AT3 predominantly involve…
KOBENHAVNS UNIVERSITET
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