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The AGTC project focuses on developing targeted lipid nanoparticles for efficient gene delivery into T cells, aiming to improve gene therapy methods. By using barcoded synthetic vectors, the project seeks to optimize the design and targeting of these nanoparticles, enhancing their effectiveness in treating various dise…
Innovation:
We recently developed a targeted lipid nanopar We recently developed a targeted lipid nanoparticle (tLNP) that can insert a gene directly into the genome of T cells in vivo, with efficiency comparable to viral methods.
This innovation creates a unique opportunity to track gene delivery using barcoded synthetic vectors.
These barcodes help us understand the key factors needed for effective DNA delivery and the biological consequences of gene transfer.Background:
Gene therapy holds gre…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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