CORDIS Project
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This project focuses on the enzyme Activation-Induced Deaminase (AID), which is crucial for adaptive immunity but also linked to certain cancers. The research aims to identify co-factors of AID and understand its targeting mechanisms in immunoglobulin genes using molecular techniques and genetically modified mice.
This proposal revolves around the enzyme Activation-Induced Deaminase (AID). AID plays a pivotal role in adaptive immunity because it is essential to introduce the lesions in the immunoglobulin genes that ultimately lead to somatic hypermutation (SHM), class switch recombination (CSR) and immunoglobulin gene conversion (Ig GC).
However, its mutagenic ability has a pernicious side effect and AID has been implicated in B lymphomas and other neoplasias.
Finally, because AID belongs to a family of c…
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