CORDIS Project
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This project investigates the Type 6 secretion system in Gram-negative bacteria, focusing on how these bacteria deliver toxins to target cells. It aims to understand the mechanisms of T6SS assembly and localization, which are crucial for bacterial competition and pathogenesis.
The Type 6 secretion system (T6SS) allows Gram-negative bacteria to deliver toxins into both eukaryotic and bacterial target cells and thus cause disease or kill competitors. T6SS is composed of four main parts: a membrane complex, a baseplate and a long spring-like sheath wrapped around an inner tube.
Sheath contraction generates a large amount of energy to push the tube with associated toxins through the baseplate and membrane complex out of the cell.
However, the reach of the T6SS tube is lim…
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