CORDIS Project
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The AINIGMA project investigates how glucose metabolism affects neuronal survival and degeneration. By studying protein interactions in human neurons, it aims to understand the mechanisms behind cell death and develop potential treatments for neurodegenerative diseases.
The high energy demand of the brain predisposes it to a variety of diseases if energy supplies are interrupted.
Neurons are particularly intolerant of inadequate energy supply and die or degenerate in either an acutely or chronically disturbed metabolic environment.Although neurodegenerative diseases are classically not considered to be caused by disturbed metabolism, bioenergetic defects are emerging as important pathophysiological mechanisms.
Several glucose-metabolizing enzymes are involved i…
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