CORDIS Project
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This project investigates the mechanisms behind TEL/AML1 acute lymphoblastic leukemia, a common childhood cancer. By studying the interplay between specific genetic factors using zebrafish models, the research aims to improve understanding of leukemia progression and develop targeted therapies.
Acute lymphoblastic leukemia is the most common childhood malignancy and is diagnosed in about 5000 children in Europe every year.
The most frequent B-type acute lymphoblastic leukemia, called TEL/AML1, is due to a chromosomal translocation that results in the fusion of two transcription factors, TEL with AML1 (also called RUNX1).
Most treatments of TEL/AML1 acute lymphoblastic leukemia result in a good outcome, although some patients suffer very late relapse which cannot be anticipated at the d…
UNIVERSITE DE RENNES I
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