CORDIS Project
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This project investigates the role of adherens junctions in cell adhesion and migration during zebrafish development. By combining biochemical and imaging techniques, it aims to uncover the mechanisms regulating these junctions, particularly focusing on the function of alpha-catenin in cell rearrangements.
Adherens junctions (AJ) play key roles in cell-cell adhesion, cell migration and cell signaling in a variety of biological processes. AJ are dynamic structures composed of cell-cell adhesion proteins (cadherin super-family), associated adaptor proteins (alpha-, and beta-catenin) and other proteins (p120) that locally regulate the actin cytoskeleton.
The functions of two components of the AJ, cadherins and beta-catenin, are well understood, but the function of alpha-catenin is not.
Significantly,…
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