CORDIS Project
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This project aims to develop a novel model to study the propagation of α-synuclein protein in Parkinson's disease. By modifying the genetic makeup of neurons, it seeks to investigate mechanisms that could block the toxic spread of this protein and slow disease progression.
A prion-like behavior of α-synuclein (AS) protein has been hypothesized in the pathogenesis of Parkinson disease (PD).
According to this hypothesis, pathogenic forms “seeds” of AS propagate from periphery into the neurons of central nervous system (CNS), where they recruit endogenous AS in the first receiving neurons, exit the cell and enter connected neurons.
The ongoing AS aggregation and cell-cell propagation is considered to induce oxidative stress, neuronal dysfunction and neuronal loss in…
AARHUS UNIVERSITET
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