CORDIS Project
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This project investigates how RNA polymerase II termination influences the selection of alternative cleavage and polyadenylation sites in gene expression. By employing innovative transcriptomic methods, it aims to clarify the mechanisms behind alternative 3’ end usage, which is crucial for understanding processes like…
The human genome contains only ~20.000 genes, however, most of them encode multiple transcripts resulting from alternative promoter usage, splicing, and 3’ end selection.
Gene 3’ ends can be defined by the positions of RNA 3’ cleavage, or the location where RNA polymerase II terminates transcription.
Alternative 3’ ends determine the properties of the encoded protein: typically its abundance, but sometimes also domain structure – as for immunoglobulin M heavy chain which is membrane-bound or sec…
UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU
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INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK
Poland, POZNAN
Type: Research institute
Activity type: Research Organisations
SME: No
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